The real surprise is that cycling can stress the heart as much as running while feeling almost polite to the body. At a steady effort, oxygen consumption and cardiac output during cycling can sit in the same aerobic zone as distance running, yet the legs report a different story, because joints avoid the repeated impact spikes that define every running stride.
Perceived effort, not just raw physiology, decides how wrecked people feel. Running loads body weight through each footstrike, driving sharp ground reaction forces and higher eccentric contractions in quadriceps and calves, which damage muscle fibers and boost inflammatory markers, so even a modest run can leave stairs painful long after heart rate returns to baseline.
Cycling shifts the cost. Fatigue comes from sustained concentric contractions in a supported, often seated posture, which allows more stable blood flow, easier thermoregulation, and finer pacing of power output, so riders can sit near the same percentage of maximal oxygen uptake while the nervous system interprets the effort as more controllable, less punishing, and therefore less exhausting.